UNE BIOCHEM 1005 FINAL EXAM

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UNE BIOCHEM 1005 FINAL EXAM

QUESTIONS & ANSWERS

Question : Somatostatin reduces the secretion of both

glucagon and insulin through which of the following mechanisms?

• Somatostatin activates an activator G-protein
• Somatostatin activates MAPK cascade
• Somatostatin activates an inhibitory G-protein
• Somatostatin uses Ca+2 as a downstream signal

CORRECT ANSWER : a. Translocation of GLUT 4

receptors to the cell surface

Question : Insulin mediated glucose uptake by muscle and

adipose tissue is a result of which of the following mechanisms?

• Translocation of GLUT 4 receptors to the cell surface
• Translocation of GLUT 1 (Na+/K+ symporter) to the

cell surface

• Passive diffusion
• Activation of protein kinase A

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CORRECT ANSWER : a. To move ammonia from

skeletal muscle to the liver

Question : The alanine - glucose cycle is primarily used

for which of the following purposes?

• To move ammonia from skeletal muscle to the liver
• To generate ATP for the skeletal muscle
• To move glucose from the skeletal muscle to the liver
• To move alanine from the liver to the skeletal muscle

CORRECT ANSWER : a. Protein kinase A mediated

phosphorylation of glycogen phosphorylase

Question : Which statement best illustrates an example of

post translational gene regulation?

• Protein kinase A mediated phosphorylation of glycogen

phosphorylase

• Cortisol binds a cytosolic receptor, translocates to the

nucleus and binds a GRE

• Iron binding the iron response elements binding protein

(IRE_BP) allowing for translation of ferritin mRNA

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• DNA histone associations leading to super-coiling of

DNA

CORRECT ANSWER : d. Insulin-like growth factor

(IGF)

Question : We have an expert-written solution to this

problem! Which of the following hormones is released from the liver in response to increased levels of growth hormone?

• Cortisol
• Thyroid hormone
• Somatostatin
• Insulin-like growth factor (IGF)

CORRECT ANSWER : c. mTOR is activated

Question : Autophagy is process involves degradation of

protein. Under conditions of high energy (HIGH ATP) which of the following is true regarding regulation of this process?

• Akt is inactive

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• AMPK is actice and phosphorylates TSC1/TSC2

Complex

• mTOR is activated
• Rheb is bound to GDP

CORRECT ANSWER : d. VLDL

Question : Synthesis of which of the following

lipoproteins would be elevated after a carbohydrate rich meal?

• HDL
• Chylomicrons
• LDL
• VLDL

CORRECT ANSWER : b. Carbamoyl phosphate

synthetase I (CPSI)

Question : The synthesis of N-acetylglutamate (NAGS) is

required for the activity of the urea cycle. This compound stimulates the activity of which of the following enzymes?