NSG 533 Adv Pharm Module 1 EXAM
QUESTIONS AND ANSWERS
Question : Which drug class is most effective in treating
erosive lesions:?
CORRECT ANSWER : PPIs
Question : Name 4 H2RAs:
CORRECT ANSWER : Cimetidine (Tagamet) Famotidine
(Pepcid) Ranitidine (Zantac) Nizatidine (Axid)
Question : What is the action of H2RAs?
CORRECT ANSWER : Decrease acid secretion by blocking
histamine 2-receptors in gastric parietal cells
Question : Name 4 benefits of H2RAs
CORRECT ANSWER : 1. Relieve GERD symptoms 2. Can
be administered prophylactically 3. More effective at controlling chronic GERD symptoms than ANTACIDS 4.Intermittent & routine dosing possible based on degree of symptom control needed.
Question : Name 2 drawbacks of H2RAs
CORRECT ANSWER : 1. Less effective in controlling
chronic GERD symptoms than PPIs 2. Renal elimination may require dose adjustment in kidney dysfunction patients
Question : What are the side effects associated with H2RAs?
CORRECT ANSWER : H/A, nausea (Cimetidine), weak
inhibitor, common drug interactions, gynecomastia, & Vit B- 12 deficiency which affects patients' tolerance
Question : Name the benefits of Antacids
CORRECT ANSWER : 1. Useful for intermittent treatment
of GERD symptoms 2. Immediate symptom relief 3. Usually well-tolerated
Question : What are the drawbacks of Antacids?
CORRECT ANSWER : 1. Requires frequent dosing 2.
Aluminum or Magnesium containing antacids may result in electrolyte imbalances esp. in pts. w/renal impairment 3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron
products, & thyroid hormones (doses should be several hours apart)
Question : What are the side effects of Antacids?
CORRECT ANSWER : May cause Constipation or Diarrhea
depending on the formulation used
Question : What is the Pharmacological Therapy
Effectiveness of Antacids?
CORRECT ANSWER : Antacids briefly neutralize gastric
acid but lacks acid-suppressive properties & are inferior to H2RAs
Question : What is the Pharmacological Therapy
Effectiveness of H2RAs?
CORRECT ANSWER : Histamine-2 Receptor Antagonists
decrease acid secretion to a lesser extent than PPIs (& are therefore inferior to PPIs)
Question : What is the Pharmacological Therapy
Effectiveness of PPIs?
CORRECT ANSWER : Proton Pump Inhibitors block the
rate-limiting step in acid secretion from gastric parietal cells & block all pathways for gastric acid secretion & therefore are better than H2RAs
Question : What is the treatment goal of pharmacological
therapy in GERD?
CORRECT ANSWER : Increase the pH of gastric content
by; 1) Direct gastric acid neutralization 2) Reduce acid production through inhibiting the stimulation of pathways to decrease GERD symptoms and prevent tissue damage
Question : Which Bariatric Surgery is effective in reducing
GERD symptoms in obese patients?
CORRECT ANSWER : Roux-en-Y gastric bypass
Question : Which Bariatric Surgery is ineffective in reducing
GERD symptoms in obese patients?