UNIT 9 MN 553 Pharmacology Updated Version Questions and Answers A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by
the body may lead to:
Question options:
Decreased effectiveness of irinotecan in the treatment of cancer
Increased adverse drug reactions, such as neutropenia
Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
Increased concerns for irinotecan being carcinogenic - AnswerIncreased adverse drug reactions, such as neutropenia
A good history of herb and supplement use is critical before prescribing because approximately ____ % of patients in the United States are using herbal products.
Question options:
10
5
38
70 - Answer38
A potential harmful effect on patients who take some herbal medication is:
Question options:
Constipation
Lead poisoning
Diarrhea
Life-threatening rash - AnswerLead poisoning
A thorough understanding of herbs is critical to patient safety. An example is the use of cinnamon to treat type II diabetes. It is important the patient uses Ceylon cinnamon, as the
commercially available cassia cinnamon contains:
Question options:
Coumadin, which may lead to bleeding problems
- / 2
Coumarin, which can cause liver and kidney damage
Cinnamic aldehyde, which is toxic to the kidney
Cinnamate eugenol, which is toxic to the liver - AnswerCoumarin, which can cause liver and kidney damage
According to traditional Chinese medicine, if a person who has a fever is given a herb that is
yang in nature, such as golden seal, the patient's illness will:
Question options:
Get worse
Get better
Not be adequately treated
Need additional herbs to treat the yang - AnswerGet worse
As drugs near the end of their patent, pharmaceutical companies may apply for the drug to
change to over-the-counter status in order to:
Question options:
Get a new patent for the over-the-counter form of the drug
Lower the costs because most prescription benefit plans do not cover generics
Market the drug to a whole new population, as they are able to market to patients instead of just providers
Continue to make large profits from their blockbuster brand-name drug - AnswerContinue to make large profits from their blockbuster brand-name drug
Carbamazepine has a Black Box Warning recommending testing for the HLA-B*1502 allele in
patients with Asian ancestry prior to starting therapy due to:
Question options:
Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA- B*1502 allele
Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 Allele
- / 2