PTCB drug interactions
Acetaminophen (Ans- interacts with phenytoin and carbamazepine - increase rate of liver toxicity, after acetaminophen overdose.
Adenosine (Ans- Dipyridamole blocks cellular uptake of adenosine. Theophylline is a competitive antagonist at adenosine receptors.
Epinephrine (Ans- Beta-blockers can induce widespread vasoconstriction.
Alpha blockers (Ans- Other blood pressure lowering drugs increase risk of first-dose hypotension and hypotension risk generally thereafter.
Aminoglycosides (Ans- Loop diuretics / vancomycin increase ototoxicity risk. (damage to the ear) Cyclosporine, platinum chemotherapy, cephalosporins and vancomycin increase nephrotoxicity/kidney risk.
Amiodarone (Ans- Amiodarone increases plasma concentration of digoxin, diltiazem and verapamil - increasing risk of AV block, bradycardia and heart failure.
ACE inhibitors (Ans- Hyperkalemia risk increases when taken with other potassium- elevating drugs / supplements. Renal failure risk increases when taken with NSAIDs.
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Antidepressants (SSRIs) (Ans- MAO inhibitors. Anticoagulants increase bleeding risk of SSRIs.Avoid with QT prolonging drugs such as macrolides, quinine and antipsychotics
Antidepressants Tricyclic / related drugs (Ans- Serotonin syndrome when taken with other serotonergic drugs, such as MAO inhibitors.TCAs augment antimuscarinic and sedative effects of other drugs.
Antiemetics (H1 antagonists) (Ans- Sedation risk increases when taken with other sedative drugs - benzodiazepines .Anticholinergic effects more pronounced when taken with ipratropium / tiotropium etc.
Antifungal Drugs Fluconazole (Ans- increasing plasma concentration of phenytoin, carbamazepine, warfarin, simvastatin and sulfonylureas. Reduces the antiplatelet effect of clopidogrel.
Aspirin and NSAIDS (Ans- Antiplatelets and anticoagulant drugs increase risk of bleeding.
Benzodiazepines (Ans- Sedative risk increases with other sedation-causing drugs and substances, including alcohol and opioids.
Beta blockers (Ans- Avoid with calcium channel blockers - such as verapamil and diltiazem - as the combination can lead to bradycardia, heart failure and asystole.
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