DAT Bootcamp - Organic Chemistry 1 What position on the Chair confirmation is the most stable for large groups (lowest energy) ? - correct answer Equatorial -Placing the largest substituents in the equatorial positions usually achieve the greatest stability How do you rank Acids and Bases by charge ? (CARDIO) - correct answer If all other
factors are the same (or close to the same) then:
-The more positively charged the compound = the more acidic -The more negatively charged the compound = the more basic How do you rank Acids and Bases by the atom ? (CARDIO) - correct answer If all other factors are about the same, then *Hydrogen's acidity increases* as the atom that it's bonded to : -Goes *left-to-right across a row* on the periodic table (Increasing Electronegativity) -Goes *down a column* on the periodic table (Increasing Size) How do you rank Acids and Bases by resonance ? (CARDIO) - correct answer -The more stable the conjugate base (through resonance), the stronger the acid -The more stable the conjugate acid (through resonance), the stronger the base Resonance increases the stability of charges, therefore a *resonance stabilized conjugate base* will be a *stronger acid*, and vice versa
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