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PHAR 100 MIDTERM | QUESTIONS
AND CORRECT ANSWER S |
LATEST UPDATE | 100% PASS
Question : Key historical influences to pharmacology
CORRECT ANSWER : -Civilizations: Greece, Egypt,
China-Poison: Curare, Ergot-Religion
Question : Why was zinc oxide an important compound
CORRECT ANSWER : currently found in topical
creams (i.e. calamine)
Question : What did ancient greece, egypt, and china
contribute
CORRECT ANSWER : greece - opium - codeine +
morphineegypt - senna, purgativeschina - ephedrine (asthma)
Question : What is Curare's function as a poison +
pharmaceutical
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CORRECT ANSWER : poison = paralysis/death, drug =
anesthesia
Question : What is Ergot's function as a poison +
pharmaceutical
CORRECT ANSWER : poison = mental frenzy, burning
limbs, uterus contraction pharm = ergotamine: treats
migraines, ergonovine: arrests uterine bleeding after
childbirth
Question : What did Paul Ehrlich design
CORRECT ANSWER : organoarsenicals - binds to
parasites = cure for syphillis
Question : Name 9 basic drug development steps
CORRECT ANSWER : 1- drug discovery2- pre-
clinical3- clinical trial: initial steps4- phase 1: young
healthy people5- phase 2: people affected by disesase
(~500 ppl)6- phase 3: people affected by disease
(1000+)7- Health Canda review8- Manufacturing9 -
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Phase 4: tests over long period/taken concurrently w/
other drugs
Question : Name 6 advertising techniques
CORRECT ANSWER : -before/after-fear-offer an easy
solution-attention catching-celeb endorsement-discredit other manufacturers
Question : Name 3 drug targets
CORRECT ANSWER : -receptors-chemical rxn-
physical/chemical forces
Question : Explain ED50
CORRECT ANSWER : The dose that gives 50% of max.
response
Question : What are factors that contribute to the removal
of the drug from the body CORRECT ANSWER : Excretion: kidney (80%+ of drugs), must be water soluble (conversion needed)
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Biotransformation in liver, metabolism, feces (GI tract), saliva, sweat, milk,
Question : Define efficacy
CORRECT ANSWER : the max pharmacological
response that can be produced by a specific drug in that bio system
Question : Define potency
CORRECT ANSWER : The dose of a drug required to
produce a certain response (usually 50% of max)
Question : Define therapeutic range
CORRECT ANSWER : range of doses that keep [blood]
of a drug above the [minimum] to produce desirable response, but below the [toxic response]
Question : What are the 4 major processes of
pharmacokinetics