PHAR 100 Midterm | 165 Questions with 100% Correct Answers | Verified | Latest Update
Question :Key historical influences to pharmacology
Correct answer:-Civilizations: Greece, Egypt, China
-Poison: Curare, Ergot
-Religion
Question :Why was zinc oxide an important compound
Correct answer:currently found in topical creams (i.e.
calamine)
Question :What did ancient greece, egypt, and china
contribute
Correct answer:greece - opium - codeine + morphine
egypt - senna, purgatives china - ephedrine (asthma)
Question :What is Curare's function as a poison +
pharmaceutical
Correct answer:poison = paralysis/death, drug = anesthesia
Question :What is Ergot's function as a poison +
pharmaceutical
Correct answer:poison = mental frenzy, burning limbs, uterus
contraction pharm = ergotamine: treats migraines, ergonovine: arrests uterine bleeding after childbirth
Question :What did Paul Ehrlich design
Correct answer:organoarsenicals - binds to parasites = cure
for syphillis
Question :Name 9 basic drug development steps
Correct answer:1- drug discovery
2- pre-clinical
3- clinical trial: initial steps
4- phase 1: young healthy people
5- phase 2: people affected by disesase (~500 ppl)
6- phase 3: people affected by disease (1000+)
7- Health Canda review 8- Manufacturing
9 - Phase 4: tests over long period/taken concurrently w/ other
drugs
Question :Name 6 advertising techniques
Correct answer:-before/after
-fear -offer an easy solution -attention catching -celeb endorsement -discredit other manufacturers
Question :Name 3 drug targets
Correct answer:-receptors
-chemical rxn -physical/chemical forces
Question :Explain ED50
Correct answer:The dose that gives 50% of max. response
Question :What are factors that contribute to the removal of
the drug from the body Correct answer:Excretion: kidney (80%+ of drugs), must be water soluble (conversion needed) Biotransformation in liver, metabolism, feces (GI tract), saliva, sweat, milk,
Question :Define efficacy
Correct answer:the max pharmacological response that can be
produced by a specific drug in that bio system
Question :Define potency
Correct answer:The dose of a drug required to produce a
certain response (usually 50% of max)