NYU pharmacology exam 2 Questions With Complete Solutions Narrow spectrum penicillin - Correct Answers ✅amoxicillin, used for staphylococcus infections Broad spectrum penicillin - Correct Answers ✅ampicillin, used for gram + and gram - Extended spectrum penicillin - Correct Answers ✅Piperacillin, used for more gram - bone, joint, skin, soft tissue, respiratory tract, urinary tract infections Penicillin MOA - Correct Answers ✅interferes with cell wall synthesis, bactericidal Penicillin Adverse reactions - Correct Answers ✅GI distress, superinfection, 5%-10% of pts have allergy Penicillin contrainciations - Correct Answers ✅hx of allergy/anaphylaxis; renal insufficiency Bactericidal - Correct Answers ✅kills bacteria Bacteriostatic - Correct Answers ✅inhibits bacterial growth Beta lactamase inhibitor - Correct Answers ✅Tazobactam 1 / 4
NYU pharmacology exam 2 Questions With Complete Solutions tazobactam use - Correct Answers ✅treat bite wound infections, bloodstream infections, DM foot infections, intra- abdominal infections, pneumonia, sepsis Tazobactam Adverse reactions - Correct Answers ✅GI distress, superinfection, headache, insomina Cephalosporins MOA - Correct Answers ✅inhibit cell wall synthesis; bactericidal Cephalosporins adverse effects - Correct Answers ✅GI distress, nephrotoxicity, decresed seizure threshold, 5%-10% allergic 1st generation cephalosporins - Correct Answers ✅Cephalexin; only gram + 2nd generation cephalosporins - Correct Answers ✅Cefaclor; gram - but not psudomonas 3rd generation cephalosporins - Correct Answers ✅ceftrixane; more gram - and crosses the blood brain barrier 2 / 4
NYU pharmacology exam 2 Questions With Complete Solutions 4th generation cephalosporins - Correct Answers ✅Cefepime; gram - and gram + includes pseudomonas 5th generation cephalosporins - Correct Answers ✅Ceftaroline; treatment for MRSA Macrolides - Correct Answers ✅Erythromycin Erythromycin MOA - Correct Answers ✅inhibits protein synthesis; bacteriostatic and can be bactericidal in large doses Erythromycin uses - Correct Answers ✅Respiratory (upper), GI tract, mycoplasma, chlamydia, legionella Erythromycin adverse reactions - Correct Answers ✅GI distress, superinfection, hepatotoxicity (excreted by the liver)/ototoxicity, prolonged QT interval Erythromycin considerations - Correct Answers ✅- Contraindicated with Statins -Decreases effectiveness of oral contraceptives Lincosamides - Correct Answers ✅Clindamycin 3 / 4
NYU pharmacology exam 2 Questions With Complete Solutions Clindamycin MOA - Correct Answers ✅inhibits protein synthesis; bacteriostatic and bactericidal Clindamycin uses - Correct Answers ✅Osteomyelitis and Toxic shock syndrome -also severe PID, post-partum endometriosis, septic arthritis, skin and soft tissue infection Clindamycin side effects - Correct Answers ✅C. diff because its so broad spectrum Glycopeptides - Correct Answers ✅Vancomycin Vancomycin MOA - Correct Answers ✅inhibits cell wall synthesis; primarily active against gram + MRSA and C.diff Vancomycin Uses - Correct Answers ✅Oral: C.diff; IV: MRSA Vancomycin considerations - Correct Answers ✅-75% excreted by the kidneys (very nephrotoxic) -very caustic to the veins (rotate access/IV sites and monitor for infiltration/phlebitis) red man syndrome - Correct Answers ✅Due to rapid infusion of vancomycin (go slow to prevent
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