NUR 521 ADV PHARM EXAM 2 Newest

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NUR 521 ADV PHARM EXAM 2 Newest 2025 Complete Questions And Correct Answers (Verified Answers) |Already Graded A+||Brand New!!

which of the following anticonvulsants is contraindicated in patients with a history of hypersensitivity to tricyclic antidepressants due to structural similarity?

• phenytoin
• ethosuximide
• acetazolamide
• carbamazepine
• phenobarbital - ANSWER-d. carbamazepine

oxcarbazepine is a second generation anticonvulsant that can be preferred over carbamazepine. it is characterized by all of the

following except: 1 / 4

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• less effective than carbamazepine
• improved toxicity profile including lower incidence of

hypnatremia

• stereo-selective metabolism to S-liscarbazepine
• fewer drug interactions than carbamazepine
• does not lead to the production of 10,11 epoxide toxic

metabolite - ANSWER-b. improved toxicity profile including lower incidence of hypnatremia

(improved toxicity profile and fewer drug interactions except worse hyponatremia)

a 24 yo man with a history of partial seizures has been treated with standard anticonvulsants for several years which were not fully effective and his neurologist prescribes a new drug approved for adjunctive use in partial seizures. Unfortunately the patient develops toxic epidermal necorlysis that was diagnosed as Stevens-Johnson syndrome. The new drug

prescribed was:

• felbamate
• gabapentin 2 / 4

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• lamotrigine
• tiagabine
• vigabatrin - ANSWER-c. lamotrigine

Which is the drug of choice for neuropathic pain?

• gabapentin
• phenytoin
• flurazepam
• diazepam
• trimethadione - ANSWER-a. gabapentin

T/F: Most antiseizure drugs (other than phenytoin, tiagabine,

and VPA) are not highly bound to plasma proteins - ANSWER- True

T/F: levetiracetam inhibits synaptic vesicular protein (SV2A) in

addition to blocking N-Type presynaptic Ca2+ channels which decreases synaptic release of neurotransmitters - ANSWER-True

Benzodiazepines: 3 / 4

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• compete with the binding site of GABA on GABA-A

receptors

• require a halogen or nitro group for activity
• are structurally similar to barbiturates
• all of the above
• A and B only - ANSWER-b. require a halogen or nitro group

for activity

(A) compete with the binding site of GABA on GABAA receptors - NO, BZs bind to an allosteric site on the GABAA receptors B) require a halogen or nitro group for activity - Correct answer C) are structurally similar to barbiturates - NO, BZs are structurally distinct from the barbiturates D) all of the above - NO E) A and B only - NO)

newer hypnotic drugs:

• include zalepiclone
• have a different mechanism of action, but similar structure to

benzodiazepines

• have long-half lives
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