NR 565 Pharm Midterm Exam (Latest 2023 - 2024) New Full Questions and Answers ( Included ) 100% Correct
1. CYP2D6: Need to increase doses of SSRI, beta blockers etc. Codeine can be
deadly
2. CYP2C9: Decrease warfarin dose Test for
gene VCORC1 mutation
3. CYP3A4: Decreases elimination
Increase toxicity of Amio
- Schedule I: no accepted medical use in the US it may not be prescribed. heroin, various
opium derivatives,hallucinogenic substances
5. Schedule II: No refills, no telephone orders Narcotics,
Stimulants, Depressants
- Schedule III: Drugs in this category are considered to be at moderate or low risk for physical
dependence, and with current reasons for medical use Anabolic steroids, most barbituates and ketamine Must prescribe every 6 months, can be by phone
- Schedule IV: Abuse potential exists, but less than Sch III. Examples are: Ambien, Darvocet and
Lorazepam
8. Schedule V: Not always necessary to have a prescription
Loperamide, diphenoxylate and cough medicine with less than 200mg/100 ml pregabalin
- Preclinical research: Research of drug potential, animal testing, preparation for human testing
- Phase I: Initial clinical safety studies in humans. May be as few as 10 subjects, often healthy
volunteers
- Phase II: The study drug or treatment is given to a larger group of people (100-300) to see if
it is effective and to further evaluate its safety
- Phase III: The study drug or treatment is given to large groups of people (1,000-3,000) to confirm
its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely
- Phase IV: A study conducted after a drug has been shown to work and has been granted a license
(post-marketing surveillance study) 1 / 2
- Adrenergic agonists: Drugs that stimulate and mimic the actions of the sympathetic nervous
system. Also called sympathomimetics.
- alpha 2 agonists: Decrease sympathetic impulses from the CNS to the heart and arterioles,
causing vasodilation Lowers blood pressure, diuretic may be needed Clonodine, Methyldopa, Guanabenz
SE: dry mouth, urinary retention, weight gain etc.
- Adrenergic Antagonist: A drug that blocks the actions of the sympathetic nervous system.
17. Alpha 1 Antagonist: Decreases arterial and venous vasoconstriction
Decreases blood pressure, helps relieve bph, Diuretic may be needed -osin
- Beta adrenergic antagonists: drugs that block beta-adrenergic receptors; may be nonselective or
selective; also called beta blockers
- Beta 1 Antagonist: Effects heart muscle, blocks receptors in SA node to de- crease hr, decrease
contractility
Reduces bp, reduces arrethymias, decreases angina incidences Metoprolol
20. Beta 2 antagonist: Lowers bp
Effects lungs, bronchial constriction, avoid in asthma patients
Propranolol
21. Propranolol Interactions: do not take with acetaminophin or warfarin
22. Propanolol other uses: Migraine prophylaxis, tremor, glaucoma
- Beta Blocker teaching points: Monitor bp/hr so it's not too low report difficulty
breathing or wheezing
- alpha and beta adrenergic antagonists: Lowers BP and reduces heart failure progression
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