Nagelhout Pharm 2 Exam 1 QUESTIONS AND ANSWERS 100% SOLVED (Newest 2025)
The only depolarizing muscle relaxant in clinical use is: -
Correct Answers ✅-Succinylcholine (Anectine) -Ultra short acting Short-Acting Non-Depolarizing Blocker - Correct Answers ✅-Mivacurium Intermediate-acting non-depolarizing blockers - Correct Answers ✅Atracurium Cisatracurium Rocuronium Vecuronium Long-Acting Non-Depolarizing Blocker - Correct Answers ✅pancuronium How is acetylcholine synthesized? Metabolized by?Metabolites? - Correct Answers ✅-Synthesized in presynaptic nerve terminal by N-acetyltransferase, combines acetate and choline -Metabolized acetylcholinesterase via rapid hydrolysis into choline and acetic acid -Choline re-enters the presynaptic terminal and used to make more Ach 1 / 2
Nagelhout Pharm 2 Exam 1 QUESTIONS AND ANSWERS 100% SOLVED (Newest 2025) Single twitch test - Correct Answers ✅-A single supramaximal electrical stimulus ranging from 0.1-1.0 HZ -Requires baseline before drug administration -Only tells you 100% paralyzed (no twitch) or <100% (1 twitch) Train of Four Test - Correct Answers ✅-A series of 4 twitches at 2 Hz every 0.5 sec for 2 seconds -Reflects blockade from 70-100%; useful during onset, maintenance, and emergence -TOFR compares T4 to T1 Double Burst Stimulation - Correct Answers ✅Two short bursts of tetanus (2-4 pulses at 50 Hz) separated by 0.75sec.
- May be better at detecting fade than TOF (more Hz)
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Tetanus Test - Correct Answers ✅Generally, consists of rapid delivery of a 30, 50, or 100 Hz stimulus for 5 seconds.*Should be used sparingly for deep block assessment, painful.*