ID MCQ Part 1 Exam Questions and Answers (Solved Papers)
"With respect to steroid use in bacterial meningitis:"
- little is know about its effect
- needs to be given within 30 minutes of first dose of
- helps the antibiotics penetrate the brain
antibiotics
D)Reduces incidence of hearing loss following infection - Correct Answers ✅D)Reduces incidence of hearing loss
following infection: specifically Hib infections
Varicella vaccine side effects - Correct Answers ✅Injection site reaction (20% of kids; 25% of teens/adults) Fever (15% of kids <13 have temp >39; 10% of adults and kids have temp >37.8) Rash (vesicles- at injection site) 1-3% Disseminated vesicular rash 3-5% (within 1 mo... if in first 2 weeks, more likely WT varicella) Febrile seizure
Serious event rate: 2.6/100 000
Febrile seizure post varicella vaccine rate - Correct Answers ✅1/2500 if MMR and varicella vaccine given separately; occurring 1-2 weeks post 1 / 4
ID MCQ Part 1 Exam Questions and Answers (Solved Papers) 2x higher risk if given together in kids 12-23 mos old (but not at 4-6 yr shots) Risk of disseminated vaccine virus from varicella vaccine - Correct Answers ✅Rare. Case reports in both healthy and immunocompromised hosts.Rate of transmission of varicella vaccine virus - Correct Answers ✅Rare, case reports (usually a healthy host to an immunocompromised household contact) Risk of disseminated zoster post varicella vaccine - Correct Answers ✅can see this with immunocompromised patients, occurring months later What is the most common side effect of varicella vaccination?
- Correct Answers ✅Injection site pain (20-25%)
Fever (10-15%), more in younger kids Which patient population has the highest mortality risk with Parvovirus B19 infection? - Correct Answers ✅The fetus of a mother infected with Parvo B19 Epidemiology of Parvo B19 - Correct Answers ✅70% of clinical infections are b/w 5-15 yrs old 40-60% seroprevalence by adulthood 2 / 4
ID MCQ Part 1 Exam Questions and Answers (Solved Papers) Seasonal peaks in late winter and spring Parvo B19 transmission - Correct Answers ✅Respiratory droplet primarily (but also blood products) Transmission rate= 15-30% among susceptible household contacts Parvo B19 pathogenesis - Correct Answers ✅Virus targets erythroid precursor cells causing cell lysis and arrest of erythrogenesis (but doesn't impact myeloid cells) (despite this can still see unexplained thrombocytopenia and neutropenia in addition to anemia) Parvo B19 clinical features - Correct Answers ✅Often a biphasic illness
Day 7-10: viremia, fever, malaise, rhinorrhea; undetectable
retics BUT no clinically significant drop in hgb
Day 17-18: rash + arthralgia in some (postinfectious
phenomena) Features of Parvo B19 arthropathy - Correct Answers ✅- More common in adults (60%) 3 / 4
ID MCQ Part 1 Exam Questions and Answers (Solved Papers) -Ranges from diffuse polyarthralgia with morning stiffness to true arthritis.-Self-limited and resolves in 2-4 weeks.-Can be transiently RF positive but non-destructive arthritis Features of erythema infectiosum (Fifth Disease) - Correct Answers ✅-Benign, self-limited illness of childhood.-Avg inoculation 16-17 days
-Prodrome: headache, low-grade fever (15-30%), mild URTI sx
-Hallmark= rash in 3 stages.
1st: slap-cheek
2nd: diffuse macular rash descending to trunk and proximal
extremities
3rd: central clearing= lacy, reticulated rash on extensor
surfaces, spares palms and soles Parvo B19 complication - Correct Answers ✅Transient aplastic crisis Transient arrest in erythropoiesis causes an absolute reticulocytopenia which can result in an acute drop in hemoglobin in patients with underlying chronic hemolysis
- / 4