2024 CPPS 303 - Adipose Tissue 2 Complete Questions & Answers (Solved) 100% Correct
- What do adipocytes and other cells in adipose tissue secrete?
Answer: numerous proteins, lipids and nucleic acids
- What are adipokines?
Answer: regulatory peptides
- What are lipokines?
Answer: regulatory lipid species
- What processes do the proteins, lipids and nucleic acids secreted by adipocytes
regulate or modulate?
Answer: lipid and glucose homeostasis, energy balance, inflammation and tissue
repair
- What do the peptides, hormones and growth factors of adipocytes do?
Answer: reg ulation of appetite, energy expenditure and metabolism
- What do metabolites of adipocytes do?
Answer: Metabolic flux. insulin action/resistance
- What do inflammatory mediators of adipocytes do?
Answer: inflammation, insulin resistance
- What do novel signaling lipids of adipocytes do?
Answer: insulin sensitivity, insulin secretion, thermogenesis
- What do circulating exosomal miRNAs of adipocytes do?
Answer: gene expression in liver, macrophages, and other tissues
- What do binding proteins and precursors of adipocytes do?
Answer: vascular in tegrity, blood flow and clotting
- What are adipokines?
Answer: leptin, adiponectin and resistin
- What exclusively secretes leptin, adiponectin and resistin
Answer: mouse adipocytes. 1 / 2
- How is resistin produced in humans?
Answer: secreted by AT macrophages
- What happens if you dysregulate adipokines?
Answer: systemic metabolic dysfunction, chronic metabolic diseases and some
types of cancer
- How is leptin encoded?
Answer: by the obese gene
- Where is leptin expressed?
Answer: in adipocytes
- What does leptin do?
Answer: suppresses appetite, promoting energy expenditure, regulating heat loss
- How does leptin function?
Answer: via CNS leptin receptor
- How does leptin correlate with adipose tissue mass?
Answer: positively, low when fasting and triggers hunger
- What are non-metabolic effects of leptin?
Answer: regulation of fertility, the immune system and bone turnover
- Where is the leptin receptor?
Answer: LEPR
- What are CNS metabolic effects?
Answer: increase sympathetic flow to adipose tis- sues to increase energy
expenditure, decrease heat loss, suppress appetite
- What are peripheral metabolic effects?
Answer: Reduce hepatic gluconeogenesis, prevent peripheral insulin resistance
- What is leptin resistance?
Answer: The inability to respond to leptin despite sufficient or excess levels in circulation during accumulation of excess adipose stores
- How does leptin control appetite?
Answer:
- / 2