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UNE (University Of New England) Medical Biochemistry Midterm Exam Features Accurate And Verified Questions Covering Metabolic Pathways, Enzymatic Function, Bioenergetics, Carbohydrate And Lipid Metabolism, Protein Structure, And Clinical Correlations. Ideal For Students In Medical, Dental, Or Health Science Programs.
A deficiency in thiamine can reduce the activity of the pyruvate dehydrogenase complex. Under these conditions, you would expect to have a higher than normal blood concentration of which of the following metabolites? - ANSWER-Pyruvate
Which of the following outlines the order of prosthetic groups as they are used for catalysis within the pyruvate dehydrogenase complex (PDC)? - ANSWER-Thiamine diphosphate-> lipoamide -> FAD
After a meal, fructose 2,6-bisphosphate levels are elevated. This compound will allosterically iactivate which of the following glycolytic enzymes? - ANSWER-Phosphofructokinase -1 (PFK1)
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In order for glucose to be retained within the cell, which of the following modifications must occur? - ANSWER-Phosphorylation
Which of the following reactions is commonly used to replenish intermediates of the TCA cycle? - ANSWER-Glutamate to alpha ketoglutarate
Which of the following enzymes is correctly paired with its activator? - ANSWER-Pyruvate dehydrogenase complex; pyruvate
Which of the following intermediates of the TCA cycle is required in the cytosol for fatty acid synthesis? - ANSWER-Citrate
Pyruvate dehydrogenase kinase catalyzes a reaction that results in which of the following? - ANSWER-The phosphorylation and inactivation of E1 subunit of PDC
A 1-month old boy is brought to the emergency department in a coma after sleeping through the night and failing to awaken in the morning. He is given intravenous glucose and awakens. Serum levels of pyruvate, lactate, and alanine are elevated, whereas oxaloacetate and aspartate levels are reduced. Which of the following is the most likely diagnosis in this patient? - ANSWER-Pyruvate carboxylase deficiency
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