BCPP Review part 1 Questions With Complete Solutions ADRs of esketamine - Correct Answers ✅ADRs include GI, Sedation, BP increase, Dissociation, Urinary frequency/incontinence, Cognitive/motor impairment ADRs of trazodone - Correct Answers ✅ADRs include GI, Sedation, Dry mouth, Orthostatic hypotension, Headache, Priapism ADRs of mirtazapine - Correct Answers ✅ADRs include Sedation, Dry mouth, Appetite increase, Increased TGs ADRs of bupropion - Correct Answers ✅ADRs include GI, Dry mouth, Headache, Insomnia, Anxiety, Hypertension, Tachyarrhythmias MOA of vortioxetine - Correct Answers ✅5HT reuptake inhibition, 5HT3 antagonism, 5HT1A agonism, 5HT1B partial agonism MOA of trazodone - Correct Answers ✅5HT and NE reuptake inhibition (weak), Alpha-1 blocker (weak), 5HT2A antagonism, Histamine 1 antagonism MOA of vilazodone - Correct Answers ✅5HT reuptake inhibition, 5HT1A partial agonist 1 / 3
BCPP Review part 1 Questions With Complete Solutions MOA of mirtazapine - Correct Answers ✅Alpha 2 agonism, 5HT2 and 5HT3 antagonist, Histamine 1 antagonist ADR of antidepressants in children - Correct Answers ✅Anxiety, irritability, akathisia, behavior changes, SI Preferred antidepressants to AVOID in pregnancy - Correct Answers ✅paroxetine, venlafaxine, doxepin Preferred antidepressants in lactation - Correct Answers ✅paroxetine, sertraline Preferred antidepressants in children - Correct Answers ✅fluoxetine, escitalopram
Natural products: ADR of St John's Wort - Correct Answers
✅GI, Sexual dysfunction, HA, anxiety, fatigue, heart complications w/ anaesthesia
Natural products: DDI of St John's Wort - Correct Answers
✅Induces multiple CYP450s and Pgp
Natural products: ADR of SAMe - Correct Answers ✅GI,
flatulence, HA, insomnia, anxiety 2 / 3
BCPP Review part 1 Questions With Complete Solutions
Natural products: MOA of L-methylfolate - Correct Answers
✅Cofactor in monoamine synthesis
Natural products: MOA of St John's Wort - Correct Answers
✅MAO inhibition (weak), Monoamine transporter inhibition
Natural products: MOA of SAMe - Correct Answers ✅Methyl
donor in DA and 5HT synthesis
Landmark Trial: STAR*D Citalopram - Correct Answers
✅Remission rate 27.5%, Average 6-7 weeks, 40% required 8- 12 weeks to achieve remission
Landmark Trial: STAR*D Bupropion, sertraline, or venlafaxine
after SSRI failure - Correct Answers ✅Remission rates similar between arms (18 to 25%), no difference in tolerability or time to response
Landmark Trial: STAR*D augmentation bupropion or buspirone
- Correct Answers ✅Similar remission rates (~30%),
difference in tolerability
Landmark Trial: STAR*D lithium and T3 comparison - Correct
Answers ✅Similar remission rates (16 to 25%), difference in tolerability
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