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APHON PRINCIPLES OF CHEMO
AND BIOTHERAPY, TOP
QUESTIONS AND ANSWER S, 100%
ACCURATE. VERIFIED.
Question :Biotherapy
CORRECT ANSWER: Targeted anticancer agents also
known as biological response modifiers (BRM)
Question :Tyrosine kinase inhibitors (TKIs) are what
class
CORRECT ANSWER: Biotherapy
Question :Monoclonal antibodies (MoAbs) are what class
CORRECT ANSWE R:Biotherapy
Question :Define pharmacokinetics
CORRECT ANSWER: Study of drug absorption,
metabolism, and excretion
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Question :Define pharmacodynamics
CORRECT ANSWER: The concentration of the drug in
the body and how it produces a response
Question :Define adjuvant chemotherapy
CORRECT ANSWER: The use of chemo after another
type of therapy, such as surgery, to treat residual disease or undetectable metastasis.
Question :Define neoadjuvant chemotherapy
CORRECT ANSWER: When chemo is used
preoperatively to decrease tumor burden in order to make it easier to remove the tumor surgically.
Question :Define sanctuary sites
CORRECT ANSWER: Sites within the body where
tumor cells sequester and are not easily reached by chemo such as the CNS
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Question :What normal cells are most often effected by
chemotherapy
CORRECT ANSWER: Hematopoietic, mucosal (mouth
& GI), hair follicles
Question :Why use chemotherapy
CORRECT ANSWER: To prevent cancer cells from
dividing, metastasizing, and ultimately causing the death of the patient
Question :Cure
CORRECT ANSWER: To permanently eradicate the
cancer
Question :Control
CORRECT ANSWER: To extend the length & QOL
when cure is not feasible or realistic
Question :Palliation
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CORRECT ANSWER:Minimize pain and suffering
during end of life
Question :Resting phase of cell cycle
CORRECT ANSWER: Gap 0 - cells not dividing
Question :Postmitotic phase
CORRECT ANSWER: Gap 1 - enzymes needed for
DNA synthesis are produced, protein and RNA synthesis takes place (18 Hours)
Question :Synthesis (S) Phase
CORRECT ANSWER: Cellular DNA duplicated (20
hours)
Question :Premitotic phase
CORRECT ANSWER: Gap 2 - both protein and RNA
synthesis occur, precursors of mitotic spindle are produced. Shortest phase