2024 CPPS 303 - Gut Hormones 2 | Complete Answers 100% Correct
- What does GLP-1 target to improve glucose control?
Answer:
Pancreas Liver Intestine Brain Adipose Tisue
- What does GLP-1 improve?
Answer: Insulin secretion and sensitivity
- What leads to insulin release via stimulation of exocytotic pathways and recruits
signaling mechanisms leading tot he promotion of cell proliferation and survival?
Answer: GLP-1 receptor activation
- What does GLP-1 receptor activation lead stimulate?
Answer: Proinsulin gene expression
- What does GLP-1 receptor activation enhance?
Answer: Beta cell proliferation by decreasing cell apoptosis which leads to Beta cell mass
- What are the 4 major roles of GLP-1?
Answer:
Enhances insulin secretion in a glucose dependent manner Lowers risk for hypoglycaemia Delays gastric emptying Increases satiety
- What are the positive outcomes of the major roles of GLP-1?
Answer:
Glucose control (type 2 diabetes) Weight loss (obesity) Cardioprotection
- What is the affect of GLP-1 expression on SA node myocytes?
Answer: Increased heart rate
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