IGF Binding proteins such as IGFBP3 make IGF-1 bind much better to IGF-1 receptors that expressed in muscle and adipose tissue. True False<\/p>\n\n\n\n
The correct answer and explanation is:<\/strong><\/mark><\/p>\n\n\n\n Correct Answer: False<\/strong><\/p>\n\n\n\n Explanation:<\/strong><\/p>\n\n\n\n Insulin-like Growth Factor Binding Proteins (IGFBPs), such as IGFBP-3, do not enhance the binding of IGF-1 to its receptor. Instead, they regulate the availability and activity of IGF-1 in the bloodstream and extracellular fluids. IGFBP-3 is the most abundant binding protein for IGF-1 and forms a ternary complex with IGF-1 and an acid-labile subunit (ALS). This complex helps extend the half-life of IGF-1 in circulation and prevents its rapid degradation. However, when IGF-1 is bound to IGFBP-3, it is generally not free to interact with the IGF-1 receptor.<\/p>\n\n\n\n For IGF-1 to activate the IGF-1 receptor, it must be in its free or unbound form. The IGF-1 receptor is a transmembrane tyrosine kinase receptor found on the surface of cells, especially in tissues like muscle and adipose. When free IGF-1 binds to this receptor, it triggers a cascade of intracellular signals that promote cell growth, differentiation, and survival. This is especially important in muscle development and metabolic regulation.<\/p>\n\n\n\n IGFBPs, including IGFBP-3, play a modulatory role by sequestering IGF-1 and controlling how much of it is available for receptor binding. In some cases, proteases may cleave IGFBP-3 to release IGF-1 near target tissues, indirectly supporting receptor interaction. But this is a regulated process and does not mean IGFBP-3 directly improves receptor binding.<\/p>\n\n\n\n In summary, IGFBP-3 binds IGF-1 and extends its stability but inhibits immediate binding to the IGF-1 receptor. Only when IGF-1 is released from IGFBP-3 can it effectively activate its receptor in muscle or adipose tissue. Therefore, the statement is false<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":" IGF Binding proteins such as IGFBP3 make IGF-1 bind much better to IGF-1 receptors that expressed in muscle and adipose tissue. True False The correct answer and explanation is: Correct Answer: False Explanation: Insulin-like Growth Factor Binding Proteins (IGFBPs), such as IGFBP-3, do not enhance the binding of IGF-1 to its receptor. Instead, they regulate […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-31755","post","type-post","status-publish","format-standard","hentry","category-quiz-questions"],"_links":{"self":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts\/31755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/comments?post=31755"}],"version-history":[{"count":1,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts\/31755\/revisions"}],"predecessor-version":[{"id":31756,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts\/31755\/revisions\/31756"}],"wp:attachment":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/media?parent=31755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/categories?post=31755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/tags?post=31755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}