When normal human cells are grown in a culture plate, they typically stop growing once a monolayer of cells is formed at the bottom of the plate. This arrest in division is an example of? Group of answer choices Growth factor-induced division Malfunction of the cell cycle checkpoints Density-dependent inhibition Anchorage-dependence cell division<\/p>\n\n\n\n
The correct answer and explanation is:<\/strong><\/mark><\/p>\n\n\n\n The correct answer is: Density-dependent inhibition<\/strong><\/p>\n\n\n\n When normal human cells are grown in a culture plate, they proliferate until they cover the surface of the plate in a single layer called a monolayer<\/strong>. At this point, they stop dividing, a phenomenon known as density-dependent inhibition<\/strong> or contact inhibition<\/strong>.<\/p>\n\n\n\n Density-dependent inhibition is a regulatory mechanism where cells stop dividing when they come into contact with each other. This process is essential for maintaining proper tissue architecture and preventing overcrowding. Once cells form a monolayer and fill the available space, they send signals through cell surface receptors that inhibit further cell division. This is a natural way cells regulate growth and ensure that tissues do not grow uncontrollably.<\/p>\n\n\n\n This contrasts with cancer cells, which often lose this property. Cancer cells can grow over one another and form multilayers because they no longer respond to density-dependent inhibition. This loss of contact inhibition is a hallmark of cancerous transformation.<\/p>\n\n\n\n Let\u2019s clarify why the other options are incorrect:<\/p>\n\n\n\n
\n\n\n\nExplanation (300 words):<\/h3>\n\n\n\n
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