What antibody is the primary one produced when an antigen is taken up by an M cell?<\/p>\n\n\n\n
The correct answer and explanation is:<\/strong><\/mark><\/p>\n\n\n\n Correct Answer: IgA (Immunoglobulin A)<\/strong><\/p>\n\n\n\n When an antigen is taken up by an M cell (microfold cell)<\/strong>, the primary antibody<\/strong> produced in response is Immunoglobulin A (IgA)<\/strong>, specifically the secretory form (sIgA)<\/strong>.<\/p>\n\n\n\n M cells<\/strong> are specialized epithelial cells located in the Peyer\u2019s patches<\/strong> and other mucosa-associated lymphoid tissues (MALT)<\/strong>, such as those lining the small intestine. Their key function is to sample antigens (such as bacteria, viruses, and food particles) from the intestinal lumen and deliver them to underlying immune cells, including macrophages, dendritic cells, and B lymphocytes. This process allows the immune system to monitor and respond to potential threats in the gut environment.<\/p>\n\n\n\n Once the antigen is transported across the M cell and presented to the immune cells in the lamina propria<\/strong>, B cells<\/strong> are activated. With the help of T helper cells<\/strong>, these B cells undergo class-switch recombination<\/strong> and typically differentiate into plasma cells that produce IgA<\/strong>. These IgA molecules are then transported across epithelial cells into the intestinal lumen in their secretory form (sIgA).<\/p>\n\n\n\n Secretory IgA<\/strong> is specifically adapted for mucosal immunity. It:<\/p>\n\n\n\n In contrast to systemic immune responses (which often produce IgG), mucosal immune responses are dominated by IgA<\/strong> because its structure and secretory mechanism are optimized for mucosal surfaces like the gastrointestinal, respiratory, and urogenital tracts.<\/p>\n\n\n\n In summary, the primary antibody<\/strong> produced following antigen uptake by M cells<\/strong> is IgA<\/strong>, particularly secretory IgA<\/strong>, which plays a central role in mucosal immunity<\/strong> by neutralizing pathogens while maintaining tolerance to non-harmful antigens like food and commensal microbes.<\/p>\n","protected":false},"excerpt":{"rendered":" What antibody is the primary one produced when an antigen is taken up by an M cell? The correct answer and explanation is: Correct Answer: IgA (Immunoglobulin A) Explanation (Approximately 300 Words): When an antigen is taken up by an M cell (microfold cell), the primary antibody produced in response is Immunoglobulin A (IgA), specifically […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-20525","post","type-post","status-publish","format-standard","hentry","category-quiz-questions"],"_links":{"self":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts\/20525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/comments?post=20525"}],"version-history":[{"count":1,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts\/20525\/revisions"}],"predecessor-version":[{"id":20527,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/posts\/20525\/revisions\/20527"}],"wp:attachment":[{"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/media?parent=20525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/categories?post=20525"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gaviki.com\/blog\/wp-json\/wp\/v2\/tags?post=20525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Explanation (Approximately 300 Words):<\/h3>\n\n\n\n
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