Comparing CNVs can be used to distinguish individuals.
True
False
The correct answer and explanation is:
The correct answer is True.
Copy number variations (CNVs) are a type of genetic variation that involve changes in the number of copies of a particular gene or genomic region. These variations can be detected through various molecular techniques such as array comparative genomic hybridization (aCGH) or next-generation sequencing (NGS). CNVs can either result in the gain or loss of genetic material, which can vary in size from small segments to large portions of chromosomes.
Because CNVs contribute to genetic diversity, they can be used to distinguish individuals. Each person’s genome may contain unique CNVs, or the patterns of CNVs present may be different from one individual to another. This makes CNVs a valuable tool for identifying genetic differences between individuals and even for forensic applications. For example, researchers and forensic scientists can use the specific CNV patterns of a person’s genome to establish their identity, similar to how DNA profiling is done using short tandem repeats (STRs).
Furthermore, CNVs are associated with a variety of human traits and diseases. Some CNVs are linked to genetic disorders like autism, schizophrenia, and some types of cancer. The presence or absence of specific CNVs in an individual can provide information about their susceptibility to certain conditions. This adds another layer of importance to CNV analysis, not just for distinguishing individuals but also for understanding genetic predispositions and personalized medicine.
In summary, CNVs are a significant source of genetic variation, and their unique patterns in different individuals make them useful for distinguishing between people at a molecular level.