An increase in 2, 3 DPG would cause the oxyhemoglobin dissociation to shift to the:
The correct answer and explanation is:
The correct answer is: right.
An increase in 2,3-Diphosphoglycerate (2,3-DPG) causes the oxyhemoglobin dissociation curve to shift to the right.
Explanation:
2,3-DPG is a molecule found in red blood cells that binds to deoxygenated hemoglobin. Its main role is to regulate hemoglobin’s affinity for oxygen. When 2,3-DPG levels increase, it binds to the beta chains of deoxygenated hemoglobin, stabilizing this form and making it less likely for hemoglobin to hold onto oxygen tightly.
A rightward shift of the oxyhemoglobin dissociation curve means hemoglobin releases oxygen more readily to the tissues. This shift decreases hemoglobin’s affinity for oxygen, facilitating oxygen unloading where it is most needed, such as in tissues experiencing hypoxia, high metabolic demand, or low oxygen availability.
Situations that cause an increase in 2,3-DPG include chronic hypoxia (such as at high altitude), anemia, chronic lung diseases, and conditions where oxygen delivery to tissues is compromised. By increasing 2,3-DPG, the body adapts to improve oxygen delivery despite low oxygen environments or reduced hemoglobin levels.
Conversely, a leftward shift of the curve indicates increased hemoglobin affinity for oxygen, meaning oxygen is held more tightly and less readily released to tissues. Factors causing a leftward shift include decreased 2,3-DPG, alkalosis, decreased temperature, and fetal hemoglobin presence.
In summary, an increase in 2,3-DPG reduces hemoglobin’s oxygen affinity, shifting the dissociation curve to the right and enhancing oxygen delivery to tissues under conditions that demand it.