Adhesion molecules are no longer required by memory T cells. True False
The correct answer and explanation is:
False.
Adhesion molecules remain important for memory T cells, even though they have different functional requirements compared to naïve T cells. Memory T cells are long-lived immune cells that are formed after an initial immune response to an antigen. They are crucial for providing a faster and more efficient response when the body encounters the same pathogen again.
Memory T cells do not need to constantly circulate through secondary lymphoid organs like naïve T cells, but they still require the ability to interact with other cells and tissues to mount an immune response. Adhesion molecules play a key role in this process. These molecules facilitate the interactions between T cells and other cells, such as dendritic cells, endothelial cells, and other immune cells. Specifically, adhesion molecules like integrins, selectins, and cadherins help T cells to tether and migrate to sites of infection or inflammation.
For memory T cells, the interaction with adhesion molecules allows for proper positioning at the site of antigen re-exposure. This enables them to efficiently engage with the antigen-presenting cells and respond rapidly to the pathogen. Additionally, during tissue migration, memory T cells rely on adhesion molecules to navigate through blood vessels and enter tissues. This is particularly critical because memory T cells can reside in peripheral tissues, ready to respond to re-infection.
In summary, while memory T cells have adapted to have a quicker and more targeted immune response, adhesion molecules continue to be necessary for their proper function, migration, and interaction with other immune components. These molecules are indispensable for their effective role in immunological memory and protection.